Five Mesoderm RX skincare bottles arranged on stone pedestals beside water in soft light

Rated 4.9/5 across 1,236 customers

Even, brighter-looking skin. Face to body.

Hydroquinone-free brightening for face and body, Made in the USA for over two decades.

Hydroquinone-free brightening for face and body, Made in the USA.

  • 60-Day Money-Back Guarantee
  • Cruelty-Free, Made in the USA

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What sets us apart

Skincare built around how pigment actually forms.

  • Several actives, one formula

    The serum pairs three acids; the intimate cream, five brighteners. One job each.

  • Brightening without hydroquinone

    Every formula is hydroquinone free, so it suits daily, long-term use.

  • Made to layer

    Morning and night routines designed to go together, from exfoliation to SPF.

  • A 60-Day Guarantee

    Return unused, unopened items within 60 days of delivery.

Brighter skin is a routine, not one product

Three steps in the morning, three at night, added to your cart in one tap.

Morning routine

Hydrate, brighten, then protect from UV.

Total $119.97 Ships free

Why a routine works

  • Each step has one job.Exfoliate, treat, hydrate and protect without doubling up.
  • Morning protects, night renews.Daily SPF guards the progress your night routine makes.
  • Free US shipping, built in.Every full routine clears our $59 free-shipping threshold.

New to acids or retinoids? Start every other night and patch test first.

Our values, in every bottle

For over two decades, we have made skincare we would use ourselves.

  1. Clean by defaultParaben free and sulfate free.
  2. Kind to sensitive skinDye free and fragrance free.
  3. Cruelty-freeLeaping Bunny certified.
  4. Made in the USAFormulated in the United States.
Read our story
Smiling woman holding Mesoderm RX Pigment Restraint SPF 50+ tinted emulsion

What customers reported after 60 days

said their skin feels rejuvenated
96%
said it improved the look and feel of their skin
90%
said it helped reduce the look of puffiness
93%

Based on customer study found that 92% saw brighter skin with AHA BHA PHA Dark Spot Cream, 93% experienced all-day hydration with Advanced BodyEssence, 97% noticed smoother skin with our Age-Defying Serum, and 90% of sensitive skin users had no irritation with Mesoderm RX products.

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4.9 out of 5, from 1,236 customers

In their own words, after making us part of their routine.

Try it for 60 days

If it is not right for you, return unused, unopened items within 60 days of delivery for a refund. Read the policy

  • Money-Back Guarantee
  • Easy Returns
  • Born in California, made in the USA
  • 60-day happiness guarantee
  • Cruelty-free, Leaping Bunny certified
  • Clinically-studied active ingredients

Questions, answered

Everything worth knowing before your first order.

Ask us anything
Which product is right for me?

Start with your main concern: the AHA + BHA + PHA Serum for dark spots and dullness. Pigment Restraint Cream for stubborn spots. The Intimate Brightening Cream for underarms and the bikini line. And Pigment Restraint Anti SunSpot SPF 50+ every morning. Not sure? Ask us.

Are your products suitable for sensitive skin?

Our formulas are fragrance free, dye free, paraben free and sulfate free. Any brightening active can tingle at first, so patch test and introduce one new product at a time.

How long until I see a difference?

Skin renews gradually, so give any brightening routine consistent daily use over several weeks before judging results. Individual results vary.

How fast is shipping?

Orders ship within 1 to 2 business days. Standard US shipping takes 3 to 5 business days and is free on orders over $59. 

What if it is not right for me?

Unused, unopened items can be returned within 60 days of delivery under our money-back guarantee. If an item arrives damaged or incorrect, contact us within 7 days and we will replace or refund it. Read the full policy.

How do subscriptions work?

Choose Subscribe & Save on every delivery. There is no commitment: skip, reschedule or cancel anytime from your account.

Woman smiling and holding Pigment Restraint Ultra High Sun Protection

Daily sun protection

Pigment Restraint Ultra High Sun Protection

4.9/5 from 1,236 customers

Shields skin from the UV damage that leads to dark spots.

  • Protects against environmental stressors
  • Helps even out the look of skin tone
  • Supports healthy-looking radiance
Customers holding their mesoderm RX products

Two decades of trusted skincare

For over two decades, mesoderm RX has made effective skincare you can trust. Our cruelty-free formulas leave out hydroquinone, parabens, mineral oil, petrolatum, sulfates and phthalates.

  • Two decades in skincare
  • Science-led formulas
  • Hydroquinone-free
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60-Day Money-Back Guarantee

Collagen Revitalizer bottle beside a swatch of the cream

Feel the difference with every application

Unlock your best skin yet

Collagen Revitalizer hydrates, brightens and renews for a glow you will love.

  • High-potency formulaMade with actives chosen for visible results.
  • Lightweight, fast-absorbingA cream that sinks in without a greasy feel.
  • Formulated in the USACarefully Selected Quality Ingredients